Two variants of HIV-1 B serotype are transmitted heterosexually in São Paulo, Brazil

Brazilian Journal of Medical and Biological Research

J. Casseb²  M.a. Hong²  C. Gonsalez²  L.f. Brígido²  A.j.s. Duarte²  R. Michael-hendry¹ 

[1] ,Universidade de São Paulo, São Paulo

关键词: HIV;    serotyping;    gp 120 V3 loop;    synthetic peptides;    sexual transmission;   

DOI  :  10.1590/S0100-879X1998001000002

来源: SciELO

【 摘 要 】

HIV-1 variability may have an important impact on transmission and pathogenicity. Better characterization of the HIV epidemic in Brazil is necessary for the development of vaccine trials in this country. We analyzed sera from 108 HIV-1-infected volunteers from São Paulo City to determine serotype and reactivity for V3 motifs of HIV in this population, and the relationship to transmission mode. We concluded that the HIV-1 B serotype is frequent among heterosexually infected women, even in the absence of anal sex, and that two major V3 motifs, GPGR and GWGR, had similar prevalence among women (48% and 52%, respectively) and men (56% and 44%, respectively). We also observed an equal distribution of these strains regardless of their CD4+ T cell counts, clinical status, and mode of transmission. Even though V3 serology for HIV-1 subtyping is an inexpensive tool for use in developing countries, additional methods, such as heteroduplex mobility assay and direct DNA sequencing, should be included to determine HIV-1 genetic diversity.

【 授权许可】

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