Fatal Human herpesvirus 1 (HHV-1) infection in captive marmosets (Callithrix jacchus and Callithrix penicillata) in Brazil: clinical and pathological characterization

Pesquisa Veterinária Brasileira

Renata A. Casagrande²  Cláudio S. Pannuti¹  Cristina Kanamura¹  Wilton S. Freire¹  André Grespan¹  Eliana R. Matushima² 

[1] ,Universidade de São Paulo Faculdade de Medicina Veterinária e Zootecnia Departamento de PatologiaSão Paulo SP ,Brazil

关键词: Human herpesvirus 1;    marmosets;    Callithrix jacchus;    Callithrix penicillata;    herpetic infection;    viral encephalitis;    nonhuman primate pathology;    clinical signs;    immunohistochemistry;    PCR;    Herpesvirus simplex Tipo 1;    saguis;    Callithrix jacchus;    Callithrix penicillata;    infecção herpética;    encefalite viral;    patologia de primata não-humano;    sinais clínicos;    imuno-histoquímica;    PCR;   

DOI  :  10.1590/S0100-736X2014001100013

来源: SciELO

【 摘 要 】

Fatal Human herpesvirus 1 (HHV-1) was diagnosed in 12 captive marmosets (Callithrix jacchus and Callithrix penicillata) from metropolitan region of São Paulo, São Paulo State. Clinical signs were variable among the cases, but most affected marmosets presented signs associated with viral epithelial replication: oral, lingual and facial skin ulcers and hypersalivation, and viral replication in the central nervous system: prostration, seizure and aggressive behavior. Consistent microscopic findings were diffuse mild to severe nonsuppurative necrotizing meningoencephalitis with gliosis, vasculitis and neuronal necrosis. Additionally, in the brain, oral cavity, skin, adrenal gland and myoenteric plexus intranuclear inclusion bodies were present. Immunohistochemistry confirmed the presence of the HHV-1 antigen in association with lesions in the brain, oral and lingual mucosa, facial skin, adrenal gland and myoenteric plexus. HHV-1-specific polymerase chain reaction (PCR) analysis of the brain was carried out and the virus was detected in 7/8 infected marmosets. It is concluded that HHV-1 causes widespread fatal infection in marmosets.

【 授权许可】

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