Coordenação de metais a antibióticos como uma estratégia de combate à resistência bacteriana

Química Nova

Diego Pessoa Rocha²  Gabriel Ferreira Pinto²  Reinaldo Ruggiero²  Carlos Alberto De Oliveira²  Wendell Guerra²  Ana Paula Soares Fontes¹  Tatiane Teixeira Tavares¹  Ivana Marques Marzano¹  Elene Cristina Pereira-maia¹ 

[1] ,Universidade Federal de Uberlândia Instituto de Química Uberlândia MG ,Brasil

关键词: antibiotics;    metal-based drugs;    bacterial resistance;   

DOI  :  10.1590/S0100-40422011000100022

来源: SciELO

【 摘 要 】

Antibiotic resistance has been growing at an alarming rate and consequently the arsenal of effective antibiotics against Gram-negative and Gram-positive bacteria has dropped dramatically. In this sense there is a strong need to produce new substances that not only have good spectrum of activity, but having new mechanisms of action. In this regard, this paper emphasizes the coordination of metals to antibiotics as a strategy for reversing antibiotic resistance and production of new drugs, with a special focus on quinolones, fluoroquinolones, sulfonamides and tetracyclines.

【 授权许可】

CC BY-NC   
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