Coordination of metals to antibiotics as a strategy to combat bacterial resistance

Química Nova

Universidade Federal de Uberlândia, Uberlândia, Brasil¹  Pereira-Maia, Elene Cristina¹  Ruggiero, Reinaldo¹  Marzano, Ivana Marques¹  Pinto, Gabriel Ferreira¹  Tavares, Tatiane Teixeira¹  Universidade Federal de Minas Gerais, Belo Horizonte, Brasil¹  Oliveira, Carlos Alberto de¹  Universidade Federal de Juiz de Fora, Juiz de Fora, Brasil¹  Fontes, Ana Paula Soares¹  Guerra, Wendell¹  Rocha, Diego Pessoa¹ 

关键词: antibiotics;    metal-based drugs;    bacterial resistance.;   

DOI  :  10.1590/S0100-40422011000100022

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Antibiotic resistance has been growing at an alarming rate and consequently the arsenal of effective antibiotics against Gram-negative and Gram-positive bacteria has dropped dramatically. In this sense there is a strong need to produce new substances that not only have good spectrum of activity, but having new mechanisms of action. In this regard, this paper emphasizes the coordination of metals to antibiotics as a strategy for reversing antibiotic resistance and production of new drugs, with a special focus on quinolones, fluoroquinolones, sulfonamides and tetracyclines.

【 授权许可】

Unknown