Coordination of metals to antibiotics as a strategy to combat bacterial resistance

Quimica nova

Marzano, Ivana Marques¹  Tavares, Tatiane Teixeira¹  Fontes, Ana Paula Soares¹  Pereira-Maia, Elene Cristina²  Ruggiero, Reinaldo³  Pinto, Gabriel Ferreira³  Oliveira, Carlos Alberto de³  Rocha, Diego Pessoa³  Guerra, Wendell³ 

[1] Universidade Federal de Juiz de Fora, Juiz de Fora, Brasil;Universidade Federal de Minas Gerais, Belo Horizonte, Brasil;Universidade Federal de Uberlândia, Uberlândia, Brasil

关键词: antibiotics;    metal-based drugs;    bacterial resistance.;   

DOI  :  10.1590/S0100-40422011000100022

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Antibiotic resistance has been growing at an alarming rate and consequently the arsenal of effective antibiotics against Gram-negative and Gram-positive bacteria has dropped dramatically. In this sense there is a strong need to produce new substances that not only have good spectrum of activity, but having new mechanisms of action. In this regard, this paper emphasizes the coordination of metals to antibiotics as a strategy for reversing antibiotic resistance and production of new drugs, with a special focus on quinolones, fluoroquinolones, sulfonamides and tetracyclines.

【 授权许可】

CC BY