Triterpenes and antitubercular activity of Byrsonima crassa

Química Nova

Celio Takashi Higuchi²  Fernando Rogério Pavan²  Clarice Queico Fujimura Leite²  Miriam Sannomiya¹  Wagner Vilegas¹  Sergio Roberto De Andrade Leite¹  Luis Vitor S. Sacramento¹  Daisy Nakamura Sato¹ 

[1] ,Universidade Estadual Paulista Faculdade de Ciências Farmacêuticas Departamento de Ciências BiológicasAraraquara SP ,Brasil

关键词: Byrsonima crassa;    antitubercular activity;    triterpenes;   

DOI  :  10.1590/S0100-40422008000700023

来源: SciELO

【 摘 要 】

We evaluated the potential antitubercular activity of triterpenes obtained from leaves and bark of Byrsonima crassa. From chloroform extracts of the leaves, by bioassay-guided fractionation, we obtained mixtures of known triterpenes: α-amyrin, β-amyrin and their acetates, lupeol, oleanolic acid, ursolic acid and α-amyrinone. Tested against Mycobacterium tuberculosis, the triterpenes exhibited minimum inhibitory concentrations (MICs) of 31.25 - 312.25 µg/mL. β-amyrin and friedelin, isolated from the chloroform extract of bark, showed MICs of 312.25 and 125 µg/mL respectively. This is the first report of the identification and determination of the activity of B. crassa triterpenes against M. tuberculosis.

【 授权许可】

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