Triterpenes and antitubercular activity of Byrsonima crassa

Química Nova

Leite, Clarice Queico Fujimura¹  Instituto Adolfo Lutz de Ribeirão Preto, Ribeirão Preto, Brasil¹  Sato, Daisy Nakamura¹  Sannomiya, Miriam¹  Universidade Estadual Paulista, Araraquara, Brasil¹  Vilegas, Wagner¹  Leite, Sergio Roberto de Andrade¹  Pavan, Fernando Rogério¹  Higuchi, Celio Takashi¹  Sacramento, Luis Vitor S.¹ 

关键词: Byrsonima crassa;    antitubercular activity;    triterpenes.;   

DOI  :  10.1590/S0100-40422008000700023

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

We evaluated the potential antitubercular activity of triterpenes obtained from leaves and bark of Byrsonima crassa. From chloroform extracts of the leaves, by bioassay-guided fractionation, we obtained mixtures of known triterpenes: α-amyrin, β-amyrin and their acetates, lupeol, oleanolic acid, ursolic acid and α-amyrinone. Tested against Mycobacterium tuberculosis, the triterpenes exhibited minimum inhibitory concentrations (MICs) of 31.25 - 312.25 µg/mL. β-amyrin and friedelin, isolated from the chloroform extract of bark, showed MICs of 312.25 and 125 µg/mL respectively. This is the first report of the identification and determination of the activity of B. crassa triterpenes against M. tuberculosis.

【 授权许可】

Unknown