Triterpenes and antitubercular activity of Byrsonima crassa

Quimica nova

Sato, Daisy Nakamura¹  Leite, Clarice Queico Fujimura²  Sannomiya, Miriam²  Vilegas, Wagner²  Leite, Sergio Roberto de Andrade²  Pavan, Fernando Rogério²  Higuchi, Celio Takashi²  Sacramento, Luis Vitor S.² 

[1] Instituto Adolfo Lutz de Ribeirão Preto, Ribeirão Preto, Brasil;Universidade Estadual Paulista, Araraquara, Brasil

关键词: Byrsonima crassa;    antitubercular activity;    triterpenes.;   

DOI  :  10.1590/S0100-40422008000700023

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

We evaluated the potential antitubercular activity of triterpenes obtained from leaves and bark of Byrsonima crassa. From chloroform extracts of the leaves, by bioassay-guided fractionation, we obtained mixtures of known triterpenes:α-amyrin, β-amyrin and their acetates, lupeol, oleanolic acid, ursolic acid andα-amyrinone. Tested against Mycobacterium tuberculosis, the triterpenes exhibited minimum inhibitory concentrations (MICs) of 31.25 - 312.25 µg/mL. β-amyrin and friedelin, isolated from the chloroform extract of bark, showed MICs of 312.25 and 125 µg/mL respectively. This is the first report of the identification and determination of the activity of B. crassa triterpenes against M. tuberculosis.

【 授权许可】

CC BY