Métodos de obtenção, reatividade e importância biológica de 4-tiazolidinonas

Química Nova

André P. Liesen²  Thiago M. De Aquino²  Alexandre J. S. Góes²  José G. De Lima¹  Antônio R. De Faria¹  Antonio J. Alves¹ 

[1] ,Universidade Federal de Pernambuco Departamento de Antibióticos Recife PE ,Brasil

关键词: 4-thiazolidinone;    preparation methods;    reactivity;   

DOI  :  10.1590/S0100-40422008000200033

来源: SciELO

【 摘 要 】

Molecules containing the 4-thiazolidinone ring are known to possess a wide range of biological properties including antimicrobial and anti-inflammatory activities among others. These compounds can be synthesized by cyclization reactions involving alpha-haloacetic acid or alpha-mercaptoacetic acid and employed in several chemoselective reactions. Comprehensive reviews have been written on 4-thiazolidinones in 1961 by Brown and in 1980 by Singh et al. In the recent literature, some new synthesis methods for 4-thiazolidinone derivatives and several reactions have been reported. These advances warrant to review the chemical and biological properties of compounds with this important heterocycle employed in synthetic organic chemistry and medicinal chemistry.

【 授权许可】

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