Preparation methods, reactivity and biological importance of 4-thiazolidinones

Química Nova

Aquino, Thiago M. de¹  Faria, Antônio R. de¹  Alves, Antonio J.¹  Liesen, André P.¹  Lima, José G. de¹  Universidade Federal de Pernambuco, Recife, Brasil¹  Góes, Alexandre J. S.¹ 

关键词: 4-thiazolidinone;    preparation methods;    reactivity.;   

DOI  :  10.1590/S0100-40422008000200033

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Molecules containing the 4-thiazolidinone ring are known to possess a wide range of biological properties including antimicrobial and anti-inflammatory activities among others. These compounds can be synthesized by cyclization reactions involving a-haloacetic acid or a-mercaptoacetic acid and employed in several chemoselective reactions. Comprehensive reviews have been written on 4-thiazolidinones in 1961 by Brown and in 1980 by Singh et al. In the recent literature, some new synthesis methods for 4-thiazolidinone derivatives and several reactions have been reported. These advances warrant to review the chemical and biological properties of compounds with this important heterocycle employed in synthetic organic chemistry and medicinal chemistry.

【 授权许可】

Unknown