Determinação de misturas de sulfametoxazol e trimetoprima por espectroscopia eletrônica multivariada

Química Nova

Gilcélia A. Cordeiro²  Patricio Peralta-zamora²  Noemi Nagata¹  Roberto Pontarollo¹ 

[1] ,Universidade Federal do Paraná Departamento de Química Curitiba PR ,Brasil

关键词: sulfamethoxazole-trimethoprim;    multivariate calibration;    electronic spectroscopy;   

DOI  :  10.1590/S0100-40422008000200012

来源: SciELO

【 摘 要 】

In this work a multivariate spectroscopic methodology is proposed for quantitative determination of sulfamethoxazole and trimethoprim in pharmaceutical associations. The multivariate model was developed by partial least-squares regression, using twenty synthetic mixtures and the spectral region between 190 and 350 nm. In the validation stage, which involved the analysis of five synthetic mixtures, prediction errors lower that 3% were observed. The predictive capacity of the multivariate models is seriously affected by spectral changes induced by pH variations, a fact that acquires a great significance in the analysis of real samples (pharmaceuticals) that contain chemical additives.

【 授权许可】

CC BY-NC   
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