Determination of sulfamethoxazole and trimethoprim mixtures by multivariate electronic spectroscopy

Química Nova

Pontarollo, Roberto¹  Universidade Estadual de Ponta Grossa, Ponta Grossa, Brasil¹  Nagata, Noemi¹  Universidade Federal do Paraná, Curitiba, Brasil¹  Cordeiro, Gilcélia A.¹  Peralta-Zamora, Patricio¹ 

关键词: sulfamethoxazole-trimethoprim;    multivariate calibration;    electronic spectroscopy.;   

DOI  :  10.1590/S0100-40422008000200012

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

In this work a multivariate spectroscopic methodology is proposed for quantitative determination of sulfamethoxazole and trimethoprim in pharmaceutical associations. The multivariate model was developed by partial least-squares regression, using twenty synthetic mixtures and the spectral region between 190 and 350 nm. In the validation stage, which involved the analysis of five synthetic mixtures, prediction errors lower that 3% were observed. The predictive capacity of the multivariate models is seriously affected by spectral changes induced by pH variations, a fact that acquires a great significance in the analysis of real samples (pharmaceuticals) that contain chemical additives.

【 授权许可】

Unknown