Compostos organofosforados pentavalentes: histórico, métodos sintéticos de preparação e aplicações como inseticidas e agentes antitumorais

Química Nova

Viviane Martins Rebello Dos Santos¹  Claudio Luis Donnici¹  João Batista Neves Dacosta²  Janaína Marques Rodrigues Caixeiro² 

[1] ,Universidade Federal de Minas Gerais Instituto de Ciências Exatas Departamento de QuímicaBelo Horizonte MG ,Brasil

关键词: organophosphorus compounds;    insecticides;    anticancer agents;   

DOI  :  10.1590/S0100-40422007000100028

来源: SciELO

【 摘 要 】

This paper is a review of the history, synthesis and application of organophosphorus compounds, especially of those of pentavalent phosphorus, such as phosphoramidates, phosphorothioates, phosphonates and phosphonic acids with insecticide and anticancer activities. The organophosphorus compounds with agrochemical applications show great structural variety, They include not only insecticides, but also fungicides, herbicides, and others. The large variety of commercially available organophosphorus pesticides is remarkable. Even more interesting is the high efficiency of some organophosphorus compounds as anticancer agents such as cyclophosphamide and its derivatives.

【 授权许可】

CC BY-NC   
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