Organophosphorus pentavalent compounds: history, synthetic methods of preparation and application as insecticides and antitumor agents

Química Nova

Donnici, Claudio Luis¹  Caixeiro, Janaína Marques Rodrigues¹  Universidade Federal Rural do Rio de Janeiro, Seropédica, Brasil¹  Universidade Federal de Minas Gerais, Belo Horizonte, Brasil¹  Santos, Viviane Martins Rebello dos¹  DaCosta, João Batista Neves¹ 

关键词: organophosphorus compounds;    insecticides;    anticancer agents.;   

DOI  :  10.1590/S0100-40422007000100028

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

This paper is a review of the history, synthesis and application of organophosphorus compounds, especially of those of pentavalent phosphorus, such as phosphoramidates, phosphorothioates, phosphonates and phosphonic acids with insecticide and anticancer activities. The organophosphorus compounds with agrochemical applications show great structural variety, They include not only insecticides, but also fungicides, herbicides, and others. The large variety of commercially available organophosphorus pesticides is remarkable. Even more interesting is the high efficiency of some organophosphorus compounds as anticancer agents such as cyclophosphamide and its derivatives.

【 授权许可】

Unknown