Organophosphorus pentavalent compounds: history, synthetic methods of preparation and application as insecticides and antitumor agents

Quimica nova

Caixeiro, Janaína Marques Rodrigues¹  DaCosta, João Batista Neves¹  Donnici, Claudio Luis²  Santos, Viviane Martins Rebello dos² 

[1] Universidade Federal Rural do Rio de Janeiro, Seropédica, Brasil;Universidade Federal de Minas Gerais, Belo Horizonte, Brasil

关键词: organophosphorus compounds;    insecticides;    anticancer agents.;   

DOI  :  10.1590/S0100-40422007000100028

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

This paper is areview of the history, synthesis and application of organophosphorus compounds,especially of those of pentavalent phosphorus, such as phosphoramidates, phosphorothioates,phosphonates and phosphonic acids with insecticide and anticancer activities.The organophosphorus compounds with agrochemical applications show great structuralvariety, They include not only insecticides, but also fungicides, herbicides,and others. The large variety of commercially available organophosphorus pesticidesis remarkable. Even more interesting is the high efficiency of some organophosphoruscompounds as anticancer agents such as cyclophosphamide and its derivatives.

【 授权许可】

CC BY