Aspectos toxicológicos e químicos da Anatoxina-a e seus análogos

Química Nova

Vania Rodríguez²  Sidnei Moura²  Ernani Pinto²  Claudio M. P. Pereira¹  Rodolpho Campos Braga¹ 

[1] ,Universidade de São Paulo Faculdade de Ciências Farmacêuticas Departamento de Análises Clínicas e ToxicológicasSão Paulo SP ,Brasil

关键词: anatoxin-a;    algae;    alkaloids;   

DOI  :  10.1590/S0100-40422006000600036

来源: SciELO

【 摘 要 】

Anatoxin-a and its analogues are azabicyclic alkaloids that represent one of the most powerful nicotinic agonists known for the nicotinic acetylcholine receptor (nAChR). Because of this potent mechanism of action, anatoxin-a and its derivatives represent a target for the discovery of novel drugs. Their syntheses are useful for environmental monitoring and also for pharmacokinetic/pharmacodynamic and toxicological studies. Some strategies for the synthesis of anatoxin-a and analogous compounds are described herein, covering the period from 1996 to the present date. In this review, emphasis is given to the chemical and toxicological aspects of some variants of anatoxin-a, including homoanatoxin-a and anatoxin-a(s).

【 授权许可】

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