Toxicological and chemical aspects of Anatoxin-a

Química Nova

Moura, Sidnei¹  Pinto, Ernani¹  Universidade de São Paulo, São Paulo, Brasil¹  Braga, Rodolpho Campos¹  Rodríguez, Vania¹  Pereira, Claudio M. P.¹ 

关键词: anatoxin-a;    algae;    alkaloids.;   

DOI  :  10.1590/S0100-40422006000600036

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Anatoxin-a and its analogues are azabicyclic alkaloids that represent one of the most powerful nicotinic agonists known for the nicotinic acetylcholine receptor (nAChR). Because of this potent mechanism of action, anatoxin-a and its derivatives represent a target for the discovery of novel drugs. Their syntheses are useful for environmental monitoring and also for pharmacokinetic/pharmacodynamic and toxicological studies. Some strategies for the synthesis of anatoxin-a and analogous compounds are described herein, covering the period from 1996 to the present date. In this review, emphasis is given to the chemical and toxicological aspects of some variants of anatoxin-a, including homoanatoxin-a and anatoxin-a(s).

【 授权许可】

Unknown