Toxicological and chemical aspects of Anatoxin-a

Quimica nova

Moura, Sidnei¹  Pinto, Ernani¹  Braga, Rodolpho Campos¹  Rodríguez, Vania¹  Pereira, Claudio M. P.¹ 

[1] Universidade de São Paulo, São Paulo, Brasil

关键词: anatoxin-a;    algae;    alkaloids.;   

DOI  :  10.1590/S0100-40422006000600036

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Anatoxin-a and its analogues are azabicyclic alkaloids that representone of the most powerful nicotinic agonists known for the nicotinic acetylcholinereceptor (nAChR). Because of this potent mechanism of action, anatoxin-aand its derivatives represent a target for the discovery of novel drugs. Theirsyntheses are useful for environmental monitoring and also for pharmacokinetic/pharmacodynamicand toxicological studies. Some strategies for the synthesis of anatoxin-aand analogous compounds are described herein, covering the period from 1996to the present date. In this review, emphasis is given to the chemical and toxicologicalaspects of some variants of anatoxin-a, including homoanatoxin-aand anatoxin-a(s).

【 授权许可】

CC BY