O uso do forno de microondas na síntese orgânica em fase sólida

Química Nova

Cedric Stephan Graebin¹  Vera Lucia Eifler-lima¹ 

[1] ,Universidade Federal do Rio Grande do Su Faculdade de Farmácia Porto Alegre RS

关键词: microwave reactor;    solid-phase organic synthesis;    combinatorial chemistry;   

DOI  :  10.1590/S0100-40422005000100015

来源: SciELO

【 摘 要 】

Solid-phase organic synthesis (SPOS) has been considered the main strategy for the construction of combinatorial libraries, because its simplicity leads to faster synthetic procedures. In addition to that, a series of reports in the specialized literature show great advantages in the use of microwave activation, when compared to classical heating, for instance: shorter reaction times, in some cases from several hours to a few minutes, increase of selectivity and product yields, energy economy and reduction and/or elimination of solvent. This review describes the use of microwave ovens/reactors in solid phase organic synthesis, describing the advantages, equipment and reactions using both techniques.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License