The use of microwave ovens in solid-phase organic synthesis

Química Nova

Eifler-Lima, Vera Lucia¹  Graebin, Cedric Stephan¹  Universidade Federal do Rio Grande do Su, Porto Alegre¹ 

关键词: microwave reactor;    solid-phase organic synthesis;    combinatorial chemistry.;   

DOI  :  10.1590/S0100-40422005000100015

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Solid-phase organic synthesis (SPOS) has been considered the main strategy for the construction of combinatorial libraries, because its simplicity leads to faster synthetic procedures. In addition to that, a series of reports in the specialized literature show great advantages in the use of microwave activation, when compared to classical heating, for instance: shorter reaction times, in some cases from several hours to a few minutes, increase of selectivity and product yields, energy economy and reduction and/or elimination of solvent. This review describes the use of microwave ovens/reactors in solid phase organic synthesis, describing the advantages, equipment and reactions using both techniques.

【 授权许可】

Unknown