The use of microwave ovens in solid-phase organic synthesis

Quimica nova

Eifler-Lima, Vera Lucia¹  Graebin, Cedric Stephan¹ 

[1] Universidade Federal do Rio Grande do Su, Porto Alegre

关键词: microwave reactor;    solid-phase organic synthesis;    combinatorial chemistry.;   

DOI  :  10.1590/S0100-40422005000100015

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Solid-phase organicsynthesis (SPOS) has been considered the main strategy for the constructionof combinatorial libraries, because its simplicity leads to faster syntheticprocedures. In addition to that, a series of reports in the specialized literatureshow great advantages in the use of microwave activation, when compared to classicalheating, for instance: shorter reaction times, in some cases from several hoursto a few minutes, increase of selectivity and product yields, energy economyand reduction and/or elimination of solvent. This review describes the use ofmicrowave ovens/reactors in solid phase organic synthesis, describing the advantages,equipment and reactions using both techniques.

【 授权许可】

CC BY