Degradação e estabilização do diclofenaco em nanocápsulas poliméricas

Química Nova

Claudia Regina Müller²  Sandra Elisa Haas²  Valquíria Linck Bassani²  Sílvia Stanisçuaski Guterres²  Hatem Fessi¹  Maria Do Carmo R. Peralba¹  Adriana Raffin Pohlmann¹ 

[1] ,Universidade Federal do Rio Grande do Sul Faculdade de Farmácia Porto Alegre RS

关键词: nanoparticles;    diclofenac;    degradation;   

DOI  :  10.1590/S0100-40422004000400008

来源: SciELO

【 摘 要 】

The parameters which affect the degradation and stabilization of diclofenac in suspensions of nanocapsules and of the corresponding spray-dried powders were investigated. Formulations were subjected to 14 months of storage at room temperature. In addition, a study of the degradation of diclofenac was carried out by exposing the formulations or mixtures (drug and adjuvants) to UVC wavelengths. The presence of Epikuron 170® in a concentration higher than 3.06 mg/mL stabilizes the drug, avoiding its reduction or degradation. The degradation products were isolated, analyzed by gas chromatography-mass spectrometry, and identified as 2-(2',6'-dichlorophenyl)aminobenzyl alcohol and N-(2',6'-dichlorophenyl)anthranilylaldehyde.

【 授权许可】

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