Degradation and stabilization of diclofenac in polymeric nanocapsules

Química Nova

Haas, Sandra Elisa¹  Fessi, Hatem¹  Guterres, Sílvia Stanisçuaski¹  Pohlmann, Adriana Raffin¹  Universidade Federal do Rio Grande do Sul, Porto Alegre¹  Bassani, Valquíria Linck¹  Müller, Claudia Regina¹  Université de Lyon I, França¹  Peralba, Maria do Carmo R.¹ 

关键词: nanoparticles;    diclofenac;    degradation.;   

DOI  :  10.1590/S0100-40422004000400008

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The parameters which affect the degradation and stabilization of diclofenac in suspensions of nanocapsules and of the corresponding spray-dried powders were investigated. Formulations were subjected to 14 months of storage at room temperature. In addition, a study of the degradation of diclofenac was carried out by exposing the formulations or mixtures (drug and adjuvants) to UVC wavelengths. The presence of Epikuron 170® in a concentration higher than 3.06 mg/mL stabilizes the drug, avoiding its reduction or degradation. The degradation products were isolated, analyzed by gas chromatography-mass spectrometry, and identified as 2-(2',6'-dichlorophenyl)aminobenzyl alcohol and N-(2',6'-dichlorophenyl)anthranilylaldehyde.

【 授权许可】

Unknown