Mitochondrial genome sequence diversity of Indian Plasmodium falciparum isolates

Memórias do Instituto Oswaldo Cruz

Suchi Tyagi¹  Veena Pande¹  Aparup Das¹ 

关键词: malaria;    Plasmodium falciparum;    mitochondrial genome;    evolution;    India;   

DOI  :  10.1590/0074-0276130531

来源: SciELO

【 摘 要 】

We have analysed the whole mitochondrial (mt) genome sequences (each ~6 kilo nucleotide base pairs in length) of four field isolates of the malaria parasite Plasmodium falciparum collected from different locations in India. Comparative genomic analyses of mt genome sequences revealed three novel India-specific single nucleotide polymorphisms. In general, high mt genome diversity was found in Indian P. falciparum, at a level comparable to African isolates. A population phylogenetic tree placed the presently sequenced Indian P. falciparum with the global isolates, while a previously sequenced Indian isolate was an outlier. Although this preliminary study is limited to a few numbers of isolates, the data have provided fundamental evidence of the mt genome diversity and evolutionary relationships of Indian P. falciparum with that of global isolates.

【 授权许可】

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