Regulatory elements involved in the post-transcriptional control of stage-specific gene expression in Trypanosoma cruzi: a review

Memórias do Instituto Oswaldo Cruz

Patricia R Araújo¹  Santuza M Teixeira¹ 

[1] ,Universidade Federal de Minas Gerais Departamento de Bioquímica e Imunologia Belo Horizonte MG ,Brasil

关键词: Trypanosoma cruzi;    gene expression;    post-transcriptional control;    mRNA;   

DOI  :  10.1590/S0074-02762011000300002

来源: SciELO

【 摘 要 】

Trypanosoma cruzi, a protozoan parasite that causes Chagas disease, exhibits unique mechanisms for gene expression such as constitutive polycistronic transcription of protein-coding genes, RNA editing and trans-splicing. In the absence of mechanism controlling transcription initiation, organized subsets of T. cruzi genes must be post-transcriptionally co-regulated in response to extracellular signals. The mechanisms that regulate stage-specific gene expression in this parasite have become much clearer through sequencing its whole genome as well as performing various proteomic and microarray analyses, which have demonstrated that at least half of the T. cruzi genes are differentially regulated during its life cycle. In this review, we attempt to highlight the recent advances in characterising cis and trans-acting elements in the T. cruzi genome that are involved in its post-transcriptional regulatory machinery.

【 授权许可】

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