Combinatorial Control of mRNA Fates by RNA-Binding Proteins and Non-Coding RNAs

Biomolecules

Valentina Iadevaia²  André P. Gerber¹ 

[1] Department of Microbial & Cellular Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK; E-Mail

关键词: gene expression;    post-transcriptional control;    RNA-binding protein;    microRNA;    ribonucleoprotein complex;    combinatorial control;   

DOI  :  10.3390/biom5042207

来源: mdpi

【 摘 要 】

Post-transcriptional control of gene expression is mediated by RNA-binding proteins (RBPs) and small non-coding RNAs (e.g., microRNAs) that bind to distinct elements in their mRNA targets. Here, we review recent examples describing the synergistic and/or antagonistic effects mediated by RBPs and miRNAs to determine the localisation, stability and translation of mRNAs in mammalian cells. From these studies, it is becoming increasingly apparent that dynamic rearrangements of RNA-protein complexes could have profound implications in human cancer, in synaptic plasticity, and in cellular differentiation.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.