Detection of cytotoxic necrotizing factor types 1 and 2 among fecal Escherichia coli isolates from brazilian children with and without diarrhea

Memórias do Instituto Oswaldo Cruz

Ana Terezinha Tavechio²  Lilian Regina M Marques²  Cecília Mari Abe¹  Tânia At Gomes¹ 

[1] ,Instituto Adolfo Lutz Seção de Bacteriologia São Paulo SP ,Brasil

关键词: Escherichia coli;    cytotoxins;    cytotoxic necrotizing factor;    adhesins;   

DOI  :  10.1590/S0074-02762004000100014

来源: SciELO

【 摘 要 】

The enteropathogenic role of cytotoxic necrotizing factor (CNF)-producing Escherichia coli was investigated by searching cnf genes among 2074 isolates from 200 children with and 200 without acute diarrhea in Brazil. Fourteen (7%) cases versus 10 (5%) control children carried at least one cnf positive isolate (P = 0.50) and most isolates expressed CNF type 1. DNA sequences of virulence factors of extraintestinal pathogenic E. coli (ExPEC) were detected in 78.6% of CNF1-producing isolates. Besides not being associated with human acute diarrhea, the CNF1-producing isolates here identified may represent potential ExPEC transitorily composing the normal intestinal flora.

【 授权许可】

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