Anti-human immunodeficiency virus-1 antibody titers in injection drug users compared to sexually infected individuals

Memórias do Instituto Oswaldo Cruz

Vera Bongertz²  Elaine Priscilla Ouverney²  Sylvia Lm Teixeira²  Carlos Silva-de-jesus²  Mariana A Hacker¹  Mariza G Morgado²  Francisco I Bastos¹ 

[1] ,Fiocruz Instituto Oswaldo Cruz Departamento de Imunologia

关键词: human immunodeficiency virus-1;    antibodies;    injection drug users;   

DOI  :  10.1590/S0074-02762003000200007

来源: SciELO

【 摘 要 】

Sera from infected injection drug users (IDU) have shown to have antibodies against synthetic human immunodeficiency virus-1 (HIV-1) envelope peptides more frequently. In this study, reactivity of 48 IDU plasma were compared to 60 plasmas obtained from sexually infected individuals (S). The overall reactivity of plasma from IDU compared to S was higher, and the reactivity titers were much higher for IDU plasma than S. IDU plasma also showed a broader antibody response. The higher reactivity titers were observed mainly for the gp41 immunodominant epitope and V3 peptides corresponding to the consensus sequences of HIV-1 subtypes/variants prevalent in Brazil (B, F, C) indicating the specificity in the higher immune response of IDU.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License