The prevalence of human immunodeficiency virus type 1 and hepatitis C virus among injection drug users who use high risk inner-city locales in Miami, Florida

Memórias do Instituto Oswaldo Cruz

Clyde B Mccoy²  Lisa R Metsch²  Fernando Collado-mesa²  Kristopher L Arheart²  Sarah E Messiah¹  Dolores Katz¹  Paul Shapshak¹ 

[1] ,Department of Epidemiology and Public Health

关键词: hepatitis C virus;    human immunodeficiency virus 1;    co-infection;    injection drug users;   

DOI  :  10.1590/S0074-02762004000800002

来源: SciELO

【 摘 要 】

In order to estimate the prevalence of human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) co-infection in hard-to-reach intravenous drug users, 199 subjects from high-risk inner-city locales, the so called "shooting galleries", were consented, interviewed, and tested in Miami, FL, US. Positive HIV-1 status was based on repeatedly reactive ELISA and confirmatory Western Blot. Positive HCV status was based on reactive ELISA and confirmatory polymerase chain reaction techniques. Overall, 50 (25%) were not infected with either virus, 61 (31%) were HIV-1/HCV co-infected, 17 (8%) infected by HIV-1 only, and 71 (36%) infected by HCV only. The results of the multivariable analyses showed that more years using heroin was the only significant risk factor for HCV only infection (odds ratio = 1.15; 95% confidence interval = 1.07, 1.24) and for HIV-1/HCV co-infection (odds ratio = 1.17; 95% confidence interval = 1.09, 1.26). This paper demonstrates that HIV-1/HCV co-infection is highly prevalent among so called "shooting galleries".

【 授权许可】

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