Replacing oxamniquine by praziquantel against Schistosoma mansoni infection in a rural community from the sugar-cane zone of Northeast Brazil: an epidemiological follow-up

Memórias do Instituto Oswaldo Cruz

Lilian Beck²  Tereza Cristina Favre²  Otávio Sarmento Pieri²  Luciana Carvalho Zani²  Glauce Gajo Domas²  Constança Simões Barbosa¹ 

[1] ,Fiocruz Instituto Oswaldo Cruz Departamento de BiologiaRio de Janeiro RJ ,Brasil

关键词: schistosomiasis;    control;    chemotherapy;    Northeast;    Brazil;   

DOI  :  10.1590/S0074-02762001000900025

来源: SciELO

【 摘 要 】

A group of 52 villagers was followed-up for three years regarding Schistosoma mansoni infection. All villagers were periodically surveyed by the Kato-Katz method. In March 1997 and March 1998 the positives were treated with oxamniquine (15-20 mg/kg), and in March 1999, with praziquantel (60 mg/kg). All infection indices decreased substantially between March 1999 and March 2000: prevalence of infection (from 32.7% to 21.2%), prevalence of moderate/heavy infection (from 7.7% to 1.9%), intensity of infection (from 23.1 epg to 7.4 epg) and reinfection (from 35.7% to 14.3%). Negativation increased from 53.8 to 82.4. An optimistic prognostic is assumed in the short term for the introduction of praziquantel in the study area.

【 授权许可】

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