Schistosomiasis control based on repeated chemotherapy in a rural village of the sugar-cane zone in Northeast Brazil

Memórias do Instituto Oswaldo Cruz

Otávio S Pieri²  Constança S Barbosa¹  Patrícia G Moza² 

[1] ,Instituto Oswaldo Cruz Departamento de Biologia Rio de Janeiro RJ ,Brasil

关键词: schistosomiasis;    control;    chemotherapy;    epidemiology;   

DOI  :  10.1590/S0074-02761998000700048

来源: SciELO

【 摘 要 】

A schedule of repeated chemotherapy with oxamniquine, consisting of biannual treatment of school-aged (7-13 years) children and annual treatment of all other age groups, was used in a representative rural village from a highly endemic area of schistosomiasis in Pernambuco. Significant reductions in infection were obtained only after two cycles of treatment, as the overall prevalence decreased from 72.6% to 41.7% and the geometric mean egg counts per gram of faeces among positives fell from 188.4 to 76. In a school-aged cohort (n=29) three treatments at six-month intervals were necessary to significantly reduce the proportion of positives (from 75.9% to 51.7%). In a cohort of children under 7 years of age (n=20) the proportion of positives actually increased (from 30% to 45%) despite two annual treatments. Water contact was intense and host snail density was relatively high. As there is no short-term perspective of improved sanitation, auxiliary measures such as focal mollusciciding are needed for an adequate control of schistosomiasis in this and alike areas.

【 授权许可】

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