Biological screening of Brazilian medicinal plants

Memórias do Instituto Oswaldo Cruz

Tânia Maria De Almeida Alves²  Andréia Fonseca Silva²  Mitzi Brandão¹  Telma Sueli Mesquita Grandi¹  Elza De Fátima A Smânia¹  Artur Smânia Júnior¹  Carlos Leomar Zani² 

[1] ,Fundação Instituto Oswaldo Cruz Centrode Pesquisas René Rachou Laboratório de Química de ProdutosNaturaisBelo Horizonte MG ,Brasil

关键词: medicinal plants;    Artemia salina;    Biomphalaria glabrata;    Cladosporium sphaerospermum;    antibacterialactivity;    Brazil;   

DOI  :  10.1590/S0074-02762000000300012

来源: SciELO

【 摘 要 】

In this study, we screened sixty medicinal plant species from the Brazilian savanna ("cerrado") that could contain useful compounds for the control of tropical diseases. The plant selection was based on existing ethnobotanic information and interviews with local healers. Plant extracts were screened for: (a) molluscicidal activity against Biomphalaria glabrata, (b) toxicity to brine shrimp (Artemia salina L.), (c) antifungal activity in the bioautographic assay with Cladosporium sphaerospermum and (d) antibacterial activity in the agar diffusion assay against Staphylococcus aureus, Escherichia coli, Bacillus cereus and Pseudomonas aeruginosa. Forty-two species afforded extracts that showed some degree of activity in one or more of these bioassays.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License