Polygodial, the fungitoxic component from the Brazilian medicinal plant Polygonum punctatum

Memórias do Instituto Oswaldo Cruz

Tânia Maria De Almeida Alves¹  Fabiane Lacerda Ribeiro¹  Helmut Kloos¹  Carlos Leomar Zani¹ 

[1] ,Fundação do Instituto Oswaldo Cruz Centro de Pesquisas René Rachou Laboratório de Química de Produtos NaturaisBelo Horizonte MG ,Brasil

关键词: medicinal plants;    Cladosporium sphaerospermum;    antifungal;    polygodial;    sesquiterpene;    Brazil;   

DOI  :  10.1590/S0074-02762001000600016

来源: SciELO

【 摘 要 】

Polygonum punctatum (Polygonaceae) is an herb known in some regions of Brazil as "erva-de-bicho" and is used to treat intestinal disorders. The dichloromethane extract of the aerial parts of this plant showed strong activity in a bioautographic assay with the fungus Cladosporium sphaerospermum. The bioassay-guided chemical fractionation of this extract afforded the sesquiterpene dialdehyde polygodial as the active constituent. The presence of this compound with antibiotic, anti-inflammatory and anti-hyperalgesic properties in "erva-de-bicho" may account for the effects attributed by folk medicine to this plant species.

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