The Growth of Brown Adipose Tissue in Cold-acclimatized Rats after Depletion of Mast Cell Histamine by Compound 48/80

Memórias do Instituto Oswaldo Cruz

Nelson L Daló²  Aura A López-ortega²  Haity Moussatché¹ 

[1] ,Universidad Centroccidental Lisandro Alvarado

关键词: cold acclimatization;    brown adipose tissue;    histamine;    tissue growth;   

DOI  :  10.1590/S0074-02761998000200016

来源: SciELO

【 摘 要 】

Cold acclimatization (4-5°C) is accompanied by 2-3 fold increase of brown adipose tissue (BAT). This rapid growth of interscapular BAT was studied after histamine depletion. In control rats maintained at room temperature (28 ± 2°C) the BAT histamine content was 23.4 ± 5.9 (mean ± SD) µg/g of tissue and cold acclimatization (5±1°C) produced a significant increase of BAT weight, but reduced the histamine content to 8.4 ± 1.9 µg/g. The total weight of BAT after 20 days of acclimatization was unaffected by depletion of histamine due to compound 48/80. The low level of histamine in BAT of cold acclimatized rats could be due to a fast rate of amine utilization; alternatively an altered synthesis or storage process may occur during acclimatization.

【 授权许可】

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