On the mechanism of protective action of cold acclimatization against carbon tetrachloride - and ethionine-induced fatty liver

Memórias do Instituto Oswaldo Cruz

Aura Lopez De O.²  C. A. Carmona De G.¹  H. Moussatche¹ 

[1] ,Universidad Centro Occidental Lisandro Alvarado Escuela de Ciencias Veterinárias Unidade de Investigación en Ciencias FuncionalesBarquisimeto,Venezuela

关键词: cold acclimatization;    hepatic lipoprotein lipase;    fatty liver;    carbon tetrachloride;    ethionine;   

DOI  :  10.1590/S0074-02761993000200023

来源: SciELO

【 摘 要 】

In this study the hepatic lipoprotein lipase (LPL), activity was evaluated in adult female mice acclimatized at 5-C and submitted to carbon tetrachloride (CCI) or ethionine, in order to determine the possible role of this enzuyme in the fatty liver. The results were compared with those obtained in mice kept at room temperature (27-C) that the same hepatoesteatosis inducing agent. In contrast to animals kept at room temperature, in cold aclimatized mice neither the enhancement of the LPL-liver activity by the action of CCI or ethionine occurred nor the development of fatty infiltration in the liver was observed. We conclude that the low temperature induced a protective effect against CCI or ethionine-induced fatty liver that was correlated with the no-increase of the hepatic LPL activity.

【 授权许可】

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