Immune mechanisms underlying the premunition against Plasmodium falciparum malaria

Memórias do Instituto Oswaldo Cruz

Jean Louis Pérignon¹  Pierre Druilhe¹ 

[1] ,Institut Pasteur Laboratorie de Parasitologie Bio-Médicale Paris,France

关键词: malaria;    Plasmodium falciparum;    immunity;    premunition;   

DOI  :  10.1590/S0074-02761994000600013

来源: SciELO

【 摘 要 】

The most unique characteristic of a parasite when it is in its normal host is the ability to make itself tolerated, which clearly indicates that it has sophisticated means to ensure the neutrality of its host. This is true also in the case of Plasmodium falciparum, since after numerous malaria attacks an equilibrium is reached with a chronic stage of infection, characterized by a relatively low parasitemia, and low or no disease (Sergent & Parrot 1935). We shall briefly review the main characteristics of this state of "premunition", and present data suggesting that the underlying mechanisms of defense rely on the cooperation between cell and antibodies, leading to an antibody dependent cellular inhibition of the intra-erythrocytic growth of the parasite.

【 授权许可】

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