A chromosome 9 deletion in Plasmodium falciparum results in loss of cytoadherence

Memórias do Instituto Oswaldo Cruz

D. J. Kemp²  J. Thompson²  D. A. Barnes²  T. Triglia²  F. Karamalis²  C. Petersen¹  G. V. Brown²  K. P. Day¹ 

[1] ,The Walter and Eliza Hall Institute of Medical Research Royal Melbourne Hospital Victoria,Australia

关键词: chromosome deletion;    cytoadherence;    Plasmodium falciparum;    pathology;    PfEMP1;   

DOI  :  10.1590/S0074-02761992000700011

来源: SciELO

【 摘 要 】

Many lines of Plasmodium falciparum undrgo a deletion of the right end of chromosome 9 during in vitro culture accompanied by loss of cytoadherence and gametocytogenesis. Selection of cytoadherent cells from a mixed population co-selects for those with an undeleted chromosome 9 and selected cells produce gametocytes. The deletion also results in loss of expression of PfEMP1, the putative cytoadherence ligand, suggesting PfEMP1 or a regulatory gene controlling PfEMP1 expression and gametocytogenesis may be encoded in this region. We have isolated several markers for the deleted region and are currently using a YAC-P. falciparum library to investigate this region of the genome in detail.

【 授权许可】

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