Effects of bariatric surgery on the central nervous system and eating behavior in humans: a systematic review on the neuroimaging studies

Jornal Brasileiro de Psiquiatria

Hélio Tonelli²  Fernanda Mattias Sartori¹  João Caetano Dallegrave Marchesini²  João Batista Marchesini²  Denise Gianoti Tonelli² 

[1] ,Clínica Marchesini

关键词: Neuroimaging;    functional magnetic resonance;    positron emission tomography;    gastric bypass;    bariatric surgery;    Neuroimagem;    imagem por ressonância magnética;    tomografia por emissão de pósitrons;    derivação gástrica;    cirurgia bariátrica;   

DOI  :  10.1590/S0047-20852013000400007

来源: SciELO

【 摘 要 】

INTRODUCTION: Neuroimaging studies suggest that obese people might show hyperactivity of brain areas regarding reward processing, and hypoactivity of brain areas concerning cognitive control, when exposed to food cues. Although the effects of bariatric surgery on the central nervous system and eating behavior are well known, few studies have used neuroimage techniques with the aim of investigating the central effects of bariatric surgery in humans. OBJECTIVES: This paper systematically and critically reviews studies using functional neuroimaging to investigate changes on the patterns of activation of central areas related to the regulation of eating behavior after bariatric surgery. METHOD: A search on the databases Medline, Web of Science, Lilacs and Science Direct on Line, was conducted in February 2013, using the keywords "Neuroimaging", "Positron-Emission Tomography", "Magnetic Resonance Imaging", "Gastric Bypass", "Gastroplasty", "Jejunoileal Bypass", "Bariatric Surgery". RESULTS: Seven manuscripts were included; the great majority studied the central effects of Roux en Y gastric bypass, using positron emission tomography or functional magnetic resonance. CONCLUSIONS: Bariatric surgery might normalize the activity of central areas concerned with reward and incentive salience processing, as the nucleus accumbens and mesencephalic tegmental ventral area, as well as circuitries processing behavioral inhibition, as the dorsolateral prefrontal cortex.

【 授权许可】

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