Association study of the Ile349val polymorphism of the gene ADH1C and alcohol dependence

Jornal Brasileiro de Psiquiatria

André Soares Rebello²  Rodrigo Moura-neto¹  Maria Da Glória Da Costa Carvalho¹ 

[1] ,Federal University of Rio de Janeiro Medical School Rio de Janeiro RJ ,Brazil

关键词: Alcohol dehydrogenase;    polymorphism;    chemical dependence;    alcoholism;    Álcool desidrogenase;    polimorfismo;    dependência química;    alcoolismo;   

DOI  :  10.1590/S0047-20852011000100002

来源: SciELO

【 摘 要 】

OBJECTIVE: The aim of this study was to investigate the polymorphism Ile349Val of the enzyme alcohol dehydrogenase ADH1C gene among individuals with alcohol dependence syndrome (ADS) attending Alcoholics Anonymous (AA) meetings. METHODS: A total of 120 subjects residing in Rio de Janeiro city participated in this study. Subjects were divided into two groups: a group consisting of 54 individuals from the ADS group and 66 individuals that declared not having any alcohol dependence (control group). DNA was extracted from mouth epithelial cells by phenol-chloroform method and further submitted to amplification by polymerase chain reaction (PCR). RESULTS: Our results did not show differences between the genotypes of control individuals and ADS subjects. Nevertheless, we found increased rates of alcoholism in families of ADS subjects as compared to controls. CONCLUSIONS: Our results did not show any genotype difference on the ADH1C gene when control and AA genotypes are compared.

【 授权许可】

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