Experimental lagochilascariosis in X-chromosome-linked immunodeficient mice

Revista da Sociedade Brasileira de Medicina Tropical

Jaqueline Aparecida Gleice De Freitas¹  Mariana Félix De Souza Prudente¹  Mara Silvia Carvalhaes¹ 

[1] ,Federal University of Goiás Institute of Tropical Pathology and Public Health Department of Microbiology, Immunology, Parasitology and PathologyGoiânia GO ,Brazil

关键词: B1 cells;    BALB.xid mice;    Lagochilascaris minor;    Immunoglobulin;    Células de B1;    amundongos BALB.xid;    Lagochilascaris minor;    Imunoglobulina;   

DOI  :  10.1590/S0037-86822009000400005

来源: SciELO

【 摘 要 】

Lagochilascaris minor is the etiological agent of lagochilascariosis, a disease that affects the neck region and causes exudative abscesses, with eggs, adult parasites and L3/L4 larvae in the purulent exudates. Mice are now considered to be intermediate hosts for the parasite. To determine the pattern of infection in B1 cell-deficient mice, experimental lagochilascariosis was studied in BALB/c and X-chromosome-linked immunodeficient (xid) mice. BALB.xid-infected mice showed lower numbers of larvae. Third-stage larvae, fourth-stage larvae and adult parasites were found in both strains. BALB/c mice produced IgM, IgG, IgA and IgE against the crude extract and secreted/excreted antigens of the parasite. On the other hand, BALB.xid mice did not produce IgM and produced lower levels of IgG and IgA, and similar quantities of IgE.

【 授权许可】

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