Persistent Sydenham’s chorea is not associated with sustained lymphocyte dysfunction

Arquivos de Neuro-Psiquiatria

Karen Cecília De Lima Torres¹  Natália Pessoa Rocha¹  Vítor Bortolo De Rezende¹  Walderez Ornelas Dutra¹  Kenneth John Gollob¹  Francisco Cardoso¹  Antonio Lucio Teixeira¹ 

关键词: Sydenham chorea;    autoimmunity;    lymphocytes;    B1 cells;    coreia de Sydenham;    autoimunidade;    linfócitos;    células B1;   

DOI  :  10.1590/0004-282X20150179

来源: SciELO

【 摘 要 】

The mechanisms involved in the symptoms of Sydenham’s chorea (SC) remain obscure. Taking into account the autoreactive antibody-mediated hypothesis of SC pathogenesis, the persistence of chorea may be associated with increased levels of B1 lymphocytes and other lymphocyte subsets. We evaluated lymphocyte subsets, including B1 and T cells, in patients with remitted (RSC) and persistent (PSC) SC by flow cytometry. Our results showed neither difference in the frequency of T and B lymphocytes subpopulations nor in their activation and functional states. These findings undermine the view of PSC as a sustained cytotoxic cellular-mediated condition. Alternative mechanisms may explain the pathogenesis of PSC.

【 授权许可】

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