Experimental ophitoxemia produced by the opisthoglyphous lora snake (Philodryas olfersii) venom

Revista da Sociedade Brasileira de Medicina Tropical

Alexis Rodríguez-acosta¹  Karel Lemoine¹  Luis Navarrete¹  María E. Girón¹  Irma Aguilar¹ 

[1] ,Universidad Central de VenezuelaCaracas,Venezuela

关键词: Colubridae;    Haemorrhage;    Neurotoxic;    Philodryas olfersii;    Proteolytic activity;    Venom;    Colubridae;    Hemorragia;    Neurotoxinas;    Philodryas olfersii;    Atividade proteolítica;    Veneno;   

DOI  :  10.1590/S0037-86822006000200012

来源: SciELO

【 摘 要 】

Several colubrid snakes produce venomous oral secretions. In this work, the venom collected from Venezuelan opisthoglyphous (rear-fanged) Philodryas olfersii snake was studied. Different proteins were present in its venom and they were characterized by 20% SDS-PAGE protein electrophoresis. The secretion exhibited proteolytic (gelatinase) activity, which was partially purified on a chromatography ionic exchange mono Q2 column. Additionally, the haemorrhagic activity of Philodryas olfersii venom on chicken embryos, mouse skin and peritoneum was demonstrated. Neurotoxic symptoms were demonstrated in mice inoculated with Philodryas olfersii venom. In conclusion, Philodryas olfersii venom showed proteolytic, haemorrhagic, and neurotoxic activities, thus increasing the interest in the high toxic action of Philodryas venom.

【 授权许可】

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