Experimental ophitoxemia produced by the opisthoglyphous lora snake (Philodryas olfersii) venom

Revista da Sociedade Brasileira de Medicina Tropical

Aguilar, Irma¹  Navarrete, Luis¹  Girón, María E.¹  Universidad Central de Venezuela, Caracas, Venezuela¹  Rodríguez-Acosta, Alexis¹  Lemoine, Karel¹ 

关键词: Colubridae;    Haemorrhage;    Neurotoxic;    Philodryas olfersii;    Proteolytic activity;    Venom;   

DOI  :  10.1590/S0037-86822006000200012

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

Several colubrid snakes produce venomous oral secretions. In this work, the venom collected from Venezuelan opisthoglyphous (rear-fanged) Philodryas olfersii snake was studied. Different proteins were present in its venom and they were characterized by 20% SDS-PAGE protein electrophoresis. The secretion exhibited proteolytic (gelatinase) activity, which was partially purified on a chromatography ionic exchange mono Q2 column. Additionally, the haemorrhagic activity of Philodryas olfersii venom on chicken embryos, mouse skin and peritoneum was demonstrated. Neurotoxic symptoms were demonstrated in mice inoculated with Philodryas olfersii venom. In conclusion, Philodryas olfersii venom showed proteolytic, haemorrhagic, and neurotoxic activities, thus increasing the interest in the high toxic action of Philodryas venom.

【 授权许可】

Unknown