Ring enhancing intracranial lesion responding to antituberculous treatment in an HIV-infected patient

Revista do Instituto de Medicina Tropical de São Paulo

Daniela Pellegrino²  Juliana Gerhardt²  Fátima M.v. Porfírio²  Edgar De Bortholi Santos²  Rafi F. Dauar¹  Augusto C. Penalva De Oliveira¹  José E. Vidal¹ 

[1] ,Institute of Infectious Diseases Emilio Ribas Department of Infectious Diseases São Paulo SP ,Brazil

关键词: Cerebral tuberculoma;    Tuberculosis;    Central nervous system;    HIV;   

DOI  :  10.1590/S0036-46652010000500013

来源: SciELO

【 摘 要 】

Cerebral tuberculomas constitute a major differential diagnosis of cerebral toxoplasmosis in human immunodeficiency virus (HIV)-infected patients in developing countries. We report the case of a 34-year old woman co-infected with HIV and possible disseminated tuberculosis (hepatitis, lymphadenopathy, and pleural effusion) who presented a large and solitary intracranial mass lesion. Despite extensive diagnostic efforts, including brain, ganglionar, and liver biopsies, no definitive diagnosis was reached. However, a trial with first-line antituberculous drugs led to a significant clinical and radiological improvement. Atypical presentations of cerebral tuberculomas should always be considered in the differential diagnosis of intracranial mass lesions in HIV-infected patients and a trial with antituberculous drugs is a valuable strategy to infer the diagnosis in a subset of patients.

【 授权许可】

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