Synergistic action of praziquantel and host specific immune response against Schistosoma mansoni at different phases of infection

Revista do Instituto de Medicina Tropical de São Paulo

Fabio Ribeiro²  Rômulo Teixeira De Mello¹  Carlos Alberto Pereira Tavares¹  John Robert Kusel¹  Paulo Marcos Zech Coelho² 

[1] ,FIOCRUZ Centro de Pesquisas ‘René Rachou’ Laboratório de EsquistossomoseBelo Horizonte MG ,Brasil

关键词: Schistosoma mansoni;    Praziquantel;    Immune Response;    Concomitant Immunity;   

DOI  :  10.1590/S0036-46652004000400010

来源: SciELO

【 摘 要 】

The interaction between specific immune response to Schistosoma mansoni and praziquantel (PZQ) was studied in mice. In mice harboring concomitant immunity, 6-day-old parasites treated with PZQ were more effectively removed than 24h treated parasites despite both had a significant worm burden reduction when compared with respective treated controls. These results show that PZQ can be effective at the skin and lung stages of parasite's development mainly acting with a established specific immune response, and particularly at the lung phase.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License