Effect of chemokine superdiffusion on leucocyte chemotaxis

Chemotaxis;Mathematical Modelling;Immune Response;Modelling Acute Inflammation;Anomalous Diffusion;Fractional Reaction-Diffusion

Jalilzadeh, Aidin ; Baeumer, Boris ; Athens, Josie ; Frauendiener, Joerg

University of Otago

关键词: Chemotaxis;    Mathematical Modelling;    Immune Response;    Modelling Acute Inflammation;    Anomalous Diffusion;    Fractional Reaction-Diffusion;   

Others  :  https://ourarchive.otago.ac.nz/bitstream/10523/5749/1/JalilzadehAidin2014PhD.pdf

美国|英语

来源: Otago University Research Archive

【 摘 要 】

Chemotaxis is the major cytotaxic mechanism that leads the movement of phagocytes in the tissue towards the harmful agents. Loss of phagocytes ability to track and respond to danger signals can lead to chronic infections, sepsis or even death. This thesis examines the consequences of anomalous diffusion of chemokines on the chemotaxis of phagocytes in the event of acute inflammatory responses.The main driver of any chemotactic system is the corresponding chemo-attractant, which is the role given to chemokines. Allowing anomalous (fractional) diffusion with the tail index of $0