Portable lactate analyzer for measuring lactate in cerebrospinal fluid (CSF) and plasma ? method-comparison evaluations

Arquivos de Neuro-Psiquiatria

Sérgio Monteiro De Almeida¹  Jennifer Marquie-beck¹  Archana Bhatt¹  Scott Letendre¹  Allen Mccutchan¹  Ron Ellis¹ 

关键词: HIV;    cerebrospinal fluid;    clinical chemistry;    lactate;    HIV;    líquido cefalorraquidiano;    química clínica;    lactato;   

DOI  :  10.1590/0004-282X20140076

来源: SciELO

【 摘 要 】

Increased plasma lactate levels can indicate the presence of metabolic disorders in HIV infected individuals.Objective:To determine whether a portable analyzer is valid for measuring cerebrospinal fluid (CSF) and plasma lactate levels in HIV infected individuals. Method:CSF and plasma were collected from 178 subjects. Samples tested by the Accutrend® portable analyzer were compared to those tested by a reference device (SYNCHRON LX® 20). Results:The portable analyzer had in plasma sensitivity of 0.95 and specificity 0.87. For CSF the specificity was 0.95; the sensitivity 0.33; the negative predictive value was 95% and the positive predictive value 33%. Conclusions:These findings support the validity of the portable analyzer in measuring lactate concentrations in CSF that fall within the normal range. The relatively poor positive predictive value indicates that a result above the reference range may represent a “false positive test”, and should be confirmed by the reference device before concluding abnormality.

【 授权许可】

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