Dosage of lactate in the cerebrospinal fluid in infectious diseases of the central nervous system

Arquivos de Neuro-Psiquiatria

Hideraldo Luis Souza Cabeça¹  Hélio Rodrigues Gomes¹  Luís Dos Ramos Machado¹  José Antonio Livramento¹ 

[1] ,Universidade de São Paulo Faculdade de Medicina Departamento de NeurologiaSão Paulo SP ,Brasil

关键词: lactate;    cerebrospinal fluid;    central nervous infections;    ácido láctico;    líquido cefalorraqueano;    infecções do sistema nervoso central;   

DOI  :  10.1590/S0004-282X2001000600002

来源: SciELO

【 摘 要 】

This paper analyzes the diagnosis aid of the dosage of lactate in the cerebrospinal fluid (CSF) in infectious diseases of the central nervous system (CNS). We analyzed prospectively 130 samples of CSF of 116 patients with diagnoses of infectious processes in the CNS. The 130 samples of CSF were divided into five groups: 28 samples of the control group, 40 of bacterial meningitis, 22 of viral meningitis, 16 of fungal meningitis and 24 of patients presenting acquired immune deficiency syndrome (AIDS). The concentration of lactate in the CSF was elevated in the group of patients with bacterial meningitis (average = 46.2 mg/dL), fungal meningitis (average = 27.3 mg/dL) and in the AIDS group (average = 23.5 mg/dL). In the control group and viral meningitis group the lactate content in the CSF presented the reference rates according to the employed method. The lactate dosage in the CSF presented a negative correlation with glycorrhachia and positive correlation with the cellularity and total proteins of the CSF. We conclude that the lactate dosage in the CSF, although unspecific, helps to distinguish the infectious processes of the CNS.

【 授权许可】

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