Interleukin-10 may protect against progressing injury during the acute phase of ischemic stroke

Arquivos de Neuro-Psiquiatria

Gustavo G. Protti¹  Rubens J. Gagliardi¹  Wilma C. N. Forte¹  Sandra Regina S. Sprovieri¹ 

关键词: ischemic stroke;    cytokines;    inflammation;    acidente vascular cerebral isquemico;    citocinas;    inflamacao;   

DOI  :  10.1590/0004-282X20130168

来源: SciELO

【 摘 要 】

Atherosclerosis is an inflammatory disease, and ischemic stroke is one of its most common and devastating manifestations. Proinflammatory cytokines play a key role in the progression of the irreversible ischemic lesions. The presence of anti-inflammatory mediators may prevent secondary ischemic injury.Objectives 1) To assess the relationship between stroke severity and the serum levels of IL-1β, IL-2, and IL-10; and 2) To analyze the neurological outcome after 72 h of ischemic stroke onset and expression of interleukins. Method We measured the serum levels of IL-1β, IL-2, and IL-10 in 26 patients with acute stroke. Neurological impairment was scored using the National Institute of Health Stroke Scale within the first 72 h after stroke onset. Thirty healthy subjects were analyzed as controls. Results Patients with IL-10 <925.0 pg/mL presented with neurological deterioration within the first 72 h. Conclusion IL-10 may protect against ischemic injury during the acute phase of stroke.

【 授权许可】

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