Neuroprotective Mechanisms of Taurine against Ischemic Stroke

Brain Sciences

Janet Menzie¹  Howard Prentice² 

[1] Program in Integrative Biology, Florida Atlantic University, Boca Raton, FL 33431, USA; E-Mail:;Department of Biomedical Sciences, Florida Atlantic University, Boca Raton, FL 33431, USA

关键词: ischemic stroke;    taurine;    neuroprotective mechanisms;    glutamate excitotoxicity;    mitochondrial dysfunction;    endoplasmic reticulum stress;    oxidative stress;    inflammation;    clinical trial;   

DOI  :  10.3390/brainsci3020877

来源: mdpi

【 摘 要 】

Ischemic stroke exhibits a multiplicity of pathophysiological mechanisms. To address the diverse pathophysiological mechanisms observed in ischemic stroke investigators seek to find therapeutic strategies that are multifaceted in their action by either investigating multipotential compounds or by using a combination of compounds. Taurine, an endogenous amino acid, exhibits a plethora of physiological functions. It exhibits antioxidative properties, stabilizes membrane, functions as an osmoregulator, modulates ionic movements, reduces the level of pro-inflammators, regulates intracellular calcium concentration; all of which contributes to its neuroprotective effect. Data are accumulating that show the neuroprotective mechanisms of taurine against stroke pathophysiology. In this review, we describe the neuroprotective mechanisms employed by taurine against ischemic stroke and its use in clinical trial for ischemic stroke.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.